Structure of PDB 8svp Chain B

Receptor sequence
>8svpB (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLCSLKVSLQLRGED
GSVWNYKPPADSIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQI
SLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEQLLLEPMLKFHYML
KKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECN
RPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFG
ISLTERHKILHRLLQEGS
3D structure
PDB8svp Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR
ChainB
Resolution3.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WSX B V211 L240 M243 S247 F251 F281 Q285 W299 H327 L411 M425 L428 F429 V42 L67 M70 S74 F78 F108 Q112 W126 H147 L231 M245 L248 F249
BS02 YGO B L209 V211 L240 M243 S247 F251 F281 Q285 F288 W299 L411 L428 F429 L40 V42 L67 M70 S74 F78 F108 Q112 F115 W126 L231 L248 F249
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8svp, PDBe:8svp, PDBj:8svp
PDBsum8svp
PubMed38744881
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2);
Q15788

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