Structure of PDB 8stg Chain B

Receptor sequence
>8stgB (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
PKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKD
DATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN
LREYLRARRPPVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN
VLVTENNVMKIADFGLAKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV
LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWH
AVPSQRPTFKQLVEDLDRILTLTT
3D structure
PDB8stg RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations.
ChainB
Resolution3.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WCJ B L487 G488 E489 C491 F492 V495 K517 M538 E565 Y566 A567 L633 A643 F645 L16 G17 E18 C20 F21 V24 K46 M67 E94 Y95 A96 L152 A162 F164
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8stg, PDBe:8stg, PDBj:8stg
PDBsum8stg
PubMed37270847
UniProtP21802|FGFR2_HUMAN Fibroblast growth factor receptor 2 (Gene Name=FGFR2)

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