Structure of PDB 8ssn Chain B

Receptor sequence
>8ssnB (length=386) Species: 9606 (Homo sapiens) [Search protein sequence]
GNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVP
SNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRS
ISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITT
LHYPAPKRNKPTVYGVSPNRTDIMKHEGVWKKYSLTVAVKEEFLKEAAVM
KEKHPNLVQLLGVIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISS
AMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGPIKWTAPESLAYNKFS
IKSDVWAFGVLLWEIATYGMSPYPIDLSQVYELLEKDMERPEGCPEKVYE
LMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEV
3D structure
PDB8ssn A biophysical framework for double-drugging kinases.
ChainB
Resolution2.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AY7 B L359 L360 A452 T453 E481 C483 P484 I521 L241 L242 A316 T317 E342 C344 P345 I382
BS02 SKI B A288 T334 F336 M337 G340 L389 D400 F401 A188 T216 F218 M219 G222 L271 D282 F283
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8ssn, PDBe:8ssn, PDBj:8ssn
PDBsum8ssn
PubMed37590418
UniProtP00519|ABL1_HUMAN Tyrosine-protein kinase ABL1 (Gene Name=ABL1)

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