Structure of PDB 8sr9 Chain B

Receptor sequence

>8sr9B (length=1352) Species: 946362 (Salpingoeca rosetta)

AMIRQSVAAKTLLIENEDGKGSTRMEVQDFMKRFHMHASEDDKTGSPSTA
WGTLRFPTKEATAPYLRLSVNDDPEDALLFVKAMLAQKYGETYDRPSLIL
SVTGGARNFTLPPRLETAIAKGLRLAAQRTNAWVVTGGTNTGVMKLTGQI
MEALSKTQSHFIPPTIGIATYGVIIGGDDMTRGEPPKIGLEYEMHKKDPP
KTTPLDDNHNLFLLVDDGSTNKFGKEIKFRAAFENAAGQAFAAPVVTIVV
QGGPGTLGTALQAVRQGTPIVVVDGSGLAADVLAYAYNFMHNPLTRFKSY
TIDDLRQKVAQTFNPKSSQQLTNLLDSALECVQDPNLVVVYSLQESGIDE
FDDCILKAIFSSQGKLGNKLKQAMYFDQLDVAKRALSEASKNGQHNEIAA
CINDNLMAAMMHNKPHFVELYLGFDAKIYELKPSEEVAKTNITALDELPS
FALAIEELYKREAKKPHSHVQRLVSLSNTDVLGRHYRGRDLANTRAYNVL
RMDQIFARLVSKDFSVNRDFTIYDSKYDKVPGIQFRRTAQASHMLFLWAI
CLDRFRMARHFWLIGDQSIINALVASRILERLSTHRALQGPHLAEERAKM
QHNAKKFEELAVGVLGECHGSDSHMASEMLHSKNDMFNKKNAINIAYDAK
SLAFLSHPATQSVINADWYGHLKSVTSFWAVLFAFFFPFFVLPFINGAHR
LRRKFAKFYSAPYTRFISDLLSHFVLCVVTSYFVLDKLEDTISAIEWILL
VWFVALLLEELRQMIFCDGIAEYISDTWNRLDLIMITLFFVGFFTHASDP
SNQDSKVVSKGIHAFLVVVLWLRFMRYYALSKNLGPKLIMMMEMMKDVST
FVFLLLIFLIGYGVAAQSLLSPDEDFSSRTFIGVLFRPYFQIYGELFLDD
LNSEANCLGDTPFTECSRETVRMVPFFLAVYILGSNVLLVNLLIAMFNDT
YMKVQEAAEDLWRKQNYELCAEYKDRPFLPAPFILLAHVHMLFMRLLRLC
GVHTQEHEKIQDDETKRKITTFEELNTDKFLRRWERERQEMLEARVKMTN
DNVVQAMGMMDQLLEHMISFRFSLDQQAEWYVPPEEYPKSGGVKRYLIDA
SMVPLSIMCPSYDPVEYTHPSVAAQPVWADPADPRKIKFNVKDEVNGKVV
DRTSCHPSGISIDSNTGRPINPWGRTGMTGRGLLGKWGVNQAADTVVTRW
KRSPDGSILERDGKKVLEFVAIQRQDNKMWAIPGGFVDNGEDVALTSGRE
FMEEALGMGSAESKDSLAALFSSGTIVARIYCEDPRNTDNAWVETTCVNF
HDESGRHAARLKLQGGDDAEHARWMMVHGGLNLFASHRTLLQHVTSALNA
YF

3D structure

• PDB: 8sr9 Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
• Chain: B
• Resolution: 3.05 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CLR	B	F976 Y979	F886 Y889
BS02	MG	B	E850 N869	E760 N779
BS03	MG	B	W620 L621 G623	W562 L563 G565
BS04	CLR	B	L878 V898 I902	L788 V808 I812
BS05	CLR	B	F1003 R1012 P1015 F1016	F913 R922 P925 F926
BS06	CLR	B	E1009 M1013 F1016	E919 M923 F926

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005261 monoatomic cation channel activity
• GO:0005262 calcium channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0055085 transmembrane transport
• GO:0070588 calcium ion transmembrane transport
• GO:0098655 monoatomic cation transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8sr9, PDBe:8sr9, PDBj:8sr9
• PDBsum: 8sr9
• PubMed: 38773335
• UniProt: F2UB89