Structure of PDB 8sr7 Chain B

Receptor sequence

>8sr7B (length=1375) Species: 946362 (Salpingoeca rosetta)

SVAAKTLLIENEDGKGSTRMEVQDFMKRFHMHASEDDKTGSPSTAWGTLR
FPTKEATAPYLRLSVNDDPEDALLFVKAMLAQKYGETYDRPSLILSVTGG
ARNFTLPPRLETAIAKGLRLAAQRTNAWVVTGGTNTGVMKLTGQIMEALS
KTQSHFIPPTIGIATYGVIIGGDDMTRGEPPKIGLEYEMHKKDPPKTTPL
DDNHNLFLLVDDGSTNKFGKEIKFRAAFENAAGQAFAAPVVTIVVQGGPG
TLGTALQAVRQGTPIVVVDGSGLAADVLAYAYNFMHNPLTRFKSYTIDDL
RQKVAQTFNPKSSQQLTNLLDSALECVQDPNLVVVYSLQESGIDEFDDCI
LKAIFSSQGKLGNKLKQAMYFDQLDVAKRALSEASKNGQHNEIAACINDN
LMAAMMHNKPHFVELYLGFDAKIYELKPSEEVAKTNITALDELPSFALAI
EELYKREAKKPHSHVQRLVSLSNTDVLGRHYRGRDLANTRAYNVLRMDQI
FARLVSKDFSVNRDFTIYDSKYDKVPGIQFRRTAQASHMLFLWAICLDRF
RMARHFWLIGDQSIINALVASRILERLSTHRALQGPHLAEERAKMQHNAK
KFEELAVGVLGECHGSDSHMASEMLHSKNDMFNKKNAINIAYDAKSLAFL
SHPATQSVINADWYGHLKSVTSFWAVLFAFFFPFFVLPFINFSGAHRLRR
KFAKFYSAPYTRFISDLLSHFVLCVVTSYFVLDKLEDTISAIEWILLVWF
VALLLEELRQMIFCDGIAEYISDTWNRLDLIMITLFFVGFFTHASDPSNQ
DSKVVSKGIHAFLVVVLWLRFMRYYALSKNLGPKLIMMMEMMKDVSTFVF
LLLIFLIGYGVAAQSLLSPDEDFSSRTFIGVLFRPYFQIYGELFLDDLNS
EANCLGDTPFTECSRETVRMVPFFLAVYILGSNVLLVNLLIAMFNDTYMK
VQEAAEDLWRKQNYELCAEYKDRPFLPAPFILLAHVHMLFMRLLRLCGVH
TQEHEKIQDDETKRKITTFEELNTDKFLRRWERERQEMLEARVKMTNDNV
VQAMGMMDQLLEHMISFRFSLDQQATKINRLNSAVAVHGHTAEAAEWYVP
PEEYPKSGGVKRYLIDASMVPLSIMCPSYDPVEYTHPSVAAQPVWADPAD
PRKIKFNVKDEVNGKVVDRTSCHPSGISIDSNTGRPINPWGRTGMTGRGL
LGKWGVNQAADTVVTRWKRSPDGSILERDGKKVLEFVAIQRQDNKMWAIP
GGFVDNGEDVALTSGREFMEEALGMGTSADLMSAESKDSLAALFSSGTIV
ARIYCEDPRNTDNAWVETTCVNFHDESGRHAARLKLQGGDDAEHARWMMV
HGGLNLFASHRTLLQHVTSALNAYF

3D structure

• PDB: 8sr7 Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
• Chain: B
• Resolution: 1.97 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CLR	B	V942 I972 F976 Y979	V849 I879 F883 Y886
BS02	RP5	B	D1330 R1360 F1372 C1424 R1428 F1476 H1479	D1211 R1241 F1253 C1305 R1309 F1357 H1360
BS03	AMP	B	W1264 G1321 N1326 F1372	W1145 G1202 N1207 F1253
BS04	MG	B	E850 Q853 N869 D872	E757 Q760 N776 D779
BS05	MG	B	L621 I622 G623 E1114	L558 I559 G560 E1021
BS06	MG	B	G1370 E1390 D1460	G1251 E1271 D1341
BS07	CLR	B	L878 V898 F905	L785 V805 F812
BS08	CLR	B	R1012 P1015	R919 P922
BS09	CLR	B	E1009 M1013 F1016	E916 M920 F923

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005261 monoatomic cation channel activity
• GO:0005262 calcium channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0055085 transmembrane transport
• GO:0070588 calcium ion transmembrane transport
• GO:0098655 monoatomic cation transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8sr7, PDBe:8sr7, PDBj:8sr7
• PDBsum: 8sr7
• PubMed: 38773335
• UniProt: F2UB89