Structure of PDB 8snm Chain B

Receptor sequence
>8snmB (length=468) Species: 9606 (Homo sapiens) [Search protein sequence]
PMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDN
AGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLE
QFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAY
YSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDG
GKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGN
SRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETA
QKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIP
FCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFS
LIFWIPFSILVHCVDKKL
3D structure
PDB8snm Structure of mature human ADAM17/iRhom2 sheddase complex in complex with ADAM17 prodomain
ChainB
Resolution3.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.86: ADAM 17 endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H405 H409 H415 H186 H190 H196
BS02 CA B V477 N480 R482 D484 E487 D490 V247 N250 R252 D254 E257 D260
External links
PDB RCSB:8snm, PDBe:8snm, PDBj:8snm
PDBsum8snm
PubMed
UniProtP78536|ADA17_HUMAN Disintegrin and metalloproteinase domain-containing protein 17 (Gene Name=ADAM17)

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