Structure of PDB 8si9 Chain B

Receptor sequence
>8si9B (length=337) Species: 9606 (Homo sapiens) [Search protein sequence]
NTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEY
TIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAH
NMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSY
AYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEY
VVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGV
TTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYF
TKSQPARAAKIDRLSRIAFPLLFGIFNLVYWATYLNR
3D structure
PDB8si9 Structural insights into opposing actions of neurosteroids on GABA A receptors.
ChainB
Resolution2.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y4B B Q242 V243 W246 P330 Q232 V233 W236 P320
BS02 ABU B F65 R67 T130 F55 R57 T120
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004890 GABA-A receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8si9, PDBe:8si9, PDBj:8si9
PDBsum8si9
PubMed37607940
UniProtP14867|GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1 (Gene Name=GABRA1)

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