Structure of PDB 8si5 Chain B

Receptor sequence

>8si5B (length=1097) Species: 10090 (Mus musculus)

QKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHA
CFTASLAMKYSDVKLGEHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSH
SYRAKYVRLSYDTKPEIILQLLLKEWQMELPKLVISVHGGMQKFELHPRI
KQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHASRSSRKICTI
GIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNNLHSHFILVDDGT
VGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVLE
YLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKK
TFNFGQSEAVHLFQTMMECMKKKELITVFHIGSEDHQDIDVAILTALLKG
TNASAFDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRV
SFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLIRDVKQGNLP
PGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLETKRFPYPLNEL
LIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDT
SEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLA
VSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILMLE
YKTKAEMSHIPQSQLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVV
LVKMEQLPSVQEWIVIAYIFTYAIEKVREVFMSEAGKISQKIKVWFSDYF
NVSDTIAIISFFVGFGLRFGAKWNYINAYDNHVFVAGRLIYCLNIIFWYV
RLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYP
HEEPSWSLAKDIVFHPYWMIFGEVYAYEIDVCANDSTLPTICGPGTWLTP
FLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHE
KPVLPPPLIILSHIVSLFCCVCKGPKLFLTEEDQKKLHDFEEQCVEMYFD
EKDDKFNSGSEERIRVTFERVEQMSIQIKEVGDRVNYIKRSLQSLDS

3D structure

• PDB: 8si5 Structural mechanisms of TRPM7 activation and inhibition.
• Chain: B
• Resolution: 2.17 Å

Enzymatic activity

• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CLR	B	W1071 L1072	W947 L948
BS02	DU0	B	S1029 W1030	S905 W906
BS03	CLR	B	Y923 I970 F971	Y799 I846 F847
BS04	ZY8	B	M741 D745 M748 M753	M666 D670 M673 M678
BS05	DU0	B	M868 Y973	M744 Y849

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0051262 protein tetramerization
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8si5, PDBe:8si5, PDBj:8si5
• PDBsum: 8si5
• PubMed: 37156763
• UniProt: Q923J1|TRPM7_MOUSE Transient receptor potential cation channel subfamily M member 7 (Gene Name=Trpm7)