Structure of PDB 8sgf Chain B

Receptor sequence
>8sgfB (length=328) Species: 9606 (Homo sapiens) [Search protein sequence]
CPAERSGHVAVSDGRHMFVWGGYKSNYDFYLPREELWIYNMETGRWKKIN
TEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQW
ERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSF
WNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFV
FGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLF
LFGGFTTDKQPLSDAWTYCISKNEWIQFNHPYTEKPRLWHTACASDEGEV
IVFGGCANNLLVHHRAAHSNEILIFSVQ
3D structure
PDB8sgf Structure-based discovery and characterization of small molecule ligands and PROTAC degraders that co-opt the E3 ligase KLHDC2 for targeted protein degradation
ChainB
Resolution1.418 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Y50 S92 H109 K147 Y163 R189 W191 R236 R241 S269 W270 W321 H345 Y23 S60 H77 K115 Y131 R157 W159 R204 R209 S237 W238 W289 H313
External links
PDB RCSB:8sgf, PDBe:8sgf, PDBj:8sgf
PDBsum8sgf
PubMed38177675
UniProtQ9Y2U9|KLDC2_HUMAN Kelch domain-containing protein 2 (Gene Name=KLHDC2)

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