Structure of PDB 8sge Chain B

Receptor sequence

>8sgeB (length=325) Species: 9606 (Homo sapiens) [Search protein sequence]

ACPAERSGHVAVSDGRHMFVWGGYKSNDFYLPREELWIYNMETGRWKKIN
TEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSVLQWERI
DCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNS
SHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGG
RYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFG
GFTTDKQPLSDAWTYCISKNEWIQFNHPYTEKPRLWHTACASDEGEVIVF
GGCANNLLVHHRAAHSNEILIFSVQ

3D structure

PDB

8sge Structure-based discovery and characterization of small molecule ligands and PROTAC degraders that co-opt the E3 ligase KLHDC2 for targeted protein degradation

Chain

Resolution

1.509 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZWS	B	K147 Y163 W191 R236 R241 S269 W270 L343 H345	K112 Y128 W156 R201 R206 S234 W235 L308 H310

External links

PDB	RCSB:8sge, PDBe:8sge, PDBj:8sge
PDBsum	8sge
PubMed	38177675
UniProt	Q9Y2U9\|KLDC2_HUMAN Kelch domain-containing protein 2 (Gene Name=KLHDC2)

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