Structure of PDB 8sex Chain B

Receptor sequence
>8sexB (length=626) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
NFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHM
MMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLV
ESSSNVEMILKPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESK
RQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPGELEVQRVKF
LNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPNMVYYFLEESTGYM
EPALWCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYIT
EQPGDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIFGRERIAE
LLGMDLASLEDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAA
HLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRK
FYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYEL
YRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFIC
GIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVW
KMYQERCWDFFPAGDCFRKQYEDQLS
3D structure
PDB8sex Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
ChainB
Resolution2.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP B M4954 K4957 C4958 F4959 T4979 H4983 N4984 M543 K546 C547 F548 T568 H572 N573
BS02 ZN B C4958 C4961 H4978 H4983 C547 C550 H567 H572
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005219 ryanodine-sensitive calcium-release channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0015278 intracellularly gated calcium channel activity
GO:0015643 toxic substance binding
GO:0035381 ATP-gated ion channel activity
GO:0042802 identical protein binding
GO:0044325 transmembrane transporter binding
GO:0046872 metal ion binding
GO:0097718 disordered domain specific binding
Biological Process
GO:0003151 outflow tract morphogenesis
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0006936 muscle contraction
GO:0006941 striated muscle contraction
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0019722 calcium-mediated signaling
GO:0043588 skin development
GO:0043931 ossification involved in bone maturation
GO:0048741 skeletal muscle fiber development
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051289 protein homotetramerization
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0071277 cellular response to calcium ion
GO:0071313 cellular response to caffeine
Cellular Component
GO:0005790 smooth endoplasmic reticulum
GO:0014802 terminal cisterna
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0030018 Z disc
GO:0031090 organelle membrane
GO:0033017 sarcoplasmic reticulum membrane
GO:0034704 calcium channel complex
GO:0042383 sarcolemma
GO:1990425 ryanodine receptor complex

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Cellular Component
External links
PDB RCSB:8sex, PDBe:8sex, PDBj:8sex
PDBsum8sex
PubMed37192614
UniProtP11716|RYR1_RABIT Ryanodine receptor 1 (Gene Name=RYR1)

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