Structure of PDB 8sab Chain B

Receptor sequence

>8sabB (length=393) Species: 1028307 (Klebsiella aerogenes KCTC 2190)

DKHLDTALVNAGRRKKYTQGSVNSVIQRASSLVFDTVEAKKHATRNRAKG
ELFYGRRGTLTHFSLQEAMCELEGGAGCALFPCGAAAVANTILAFVEQGD
HVLMTNTAYEPSQDFCTKILAKLGVTTGWFDPLIGADIANLIQPNTKVVF
LESPGSITMEVHDVPAIVAAVRRVAPEAIIMIDNTWAAGVLFKALDFGID
ISIQAATKYLIGHSDGMIGTAVANARCWEQLCENAYLMGQMIDADTAYMT
SRGLRTLGVRLRQHHESSLRVAEWLAQHPQVARVNHPALPGSKGHEFWKR
DFSGSSGLFSFVLNKRLTDAELAAYLDNFSLFSMAYSWGGFESLILANQP
EHIAAIRPEAEVDFSGTLIRLHIGLENVDDLLADLAAGFARIV

3D structure

• PDB: 8sab Crystal Structure of Cystathionine beta lyase from Klebsiella aerogenes, PLP adduct with Alanine (C2 form)
• Chain: B
• Resolution: 1.6 Å

Enzymatic activity

• Enzyme Commision number: 4.4.1.8: Transferred entry: 4.4.1.13.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	LYS	B	L333 E344	L331 E342
BS02	LYS	B	N12 R15 R16 K17 T20	N10 R13 R14 K15 T18
BS03	PP3	B	C85 G86 A87 Y111 D185 A207 T209 K210 M219 Y338 S339 W340 R372	C83 G84 A85 Y109 D183 A205 T207 K208 M217 Y336 S337 W338 R370
BS04	PLP	B	C85 G86 A87 Y111 D185 A207 T209 K210 M219 W340	C83 G84 A85 Y109 D183 A205 T207 K208 M217 W338

Gene Ontology

Molecular Function

• GO:0016829 lyase activity
• GO:0030170 pyridoxal phosphate binding
• GO:0046872 metal ion binding
• GO:0047804 cysteine-S-conjugate beta-lyase activity

Biological Process

• GO:0006520 amino acid metabolic process
• GO:0019346 transsulfuration
• GO:0019450 L-cysteine catabolic process to pyruvate

External links

• PDB: RCSB:8sab, PDBe:8sab, PDBj:8sab
• PDBsum: 8sab
• UniProt: A0A0H3FMF8