Structure of PDB 8s98 Chain B

Receptor sequence
>8s98B (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
QLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRQELRVVLKVLDPSHHDIA
LAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRE
RGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTS
PFIKLSDPGVGLGALSREERVERIPWLAPECLPSTAMDKWGFGATLLEIC
FDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPS
FRTILRDLT
3D structure
PDB8s98 Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.
ChainB
Resolution1.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZRU B L595 G596 Q597 V640 K642 Y689 V690 P694 L741 S758 L18 G19 Q20 V38 K40 Y87 V88 P92 L139 S156
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8s98, PDBe:8s98, PDBj:8s98
PDBsum8s98
PubMed37427891
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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