Structure of PDB 8s5n Chain B

Receptor sequence
>8s5nB (length=1127) Species: 9823 (Sus scrofa) [Search protein sequence]
DEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPP
IDLQAPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLY
VDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELN
ECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCL
ETSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVS
DRDILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGV
TKEKRIKYAKEVLQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRR
ELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFN
LELAIKTRIISDGLKYSLATGNWGDQQARAGVSQVLNRLTFASTLSHLRR
LNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISV
GSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLM
NTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLL
LKKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQE
KEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMG
VYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIAS
YTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTR
ETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPTKRDCSTFLR
TSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGI
QYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIG
DATPFNDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTY
YQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAH
GAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGCRNKTQIS
LVRMPYACKLLFQELMSMSIAPRMMSV
3D structure
PDB8s5n Three-step mechanism of promoter escape by RNA polymerase II
ChainB
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B K248 G490 K218 G456
BS02 rna B Q468 R491 Q731 R890 T894 K934 K942 H1053 I1069 Q434 R457 Q697 R843 T847 K887 K895 H1006 I1022
BS03 dna B N188 K214 K494 T746 R897 G1077 R1078 R1085 N163 K189 K460 T712 R850 G1030 R1031 R1038
BS04 ZN B C1119 C1140 C1072 C1093
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8s5n, PDBe:8s5n, PDBj:8s5n
PDBsum8s5n
PubMed38604172
UniProtI3LGP4

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