Structure of PDB 8rtt Chain B

Receptor sequence

>8rttB (length=370) Species: 9606 (Homo sapiens) [Search protein sequence]

AALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVG
DEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLL
TEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDS
GDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAE
REIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERF
RCPEALFQPSFLGMESAGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTM
YPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQM
WISKQEYDESGPSIVHRKCF

3D structure

PDB

8rtt Mechanism of formin-mediated processive elongation of actin filaments revealed by cryo-EM

Chain

Resolution

3.56 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	B	G197 Y198 S199 Q246	G192 Y193 S194 Q241
BS02	peptide	B	I75 P112	I70 P107
BS03	ADP	B	G13 D157 R210 K213 E214 G302 Y306 K336	G8 D152 R205 K208 E209 G297 Y301 K331

Gene Ontology

	Molecular Function
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016887	ATP hydrolysis activity
GO:0019894	kinesin binding
GO:0019901	protein kinase binding
GO:0030957	Tat protein binding
GO:0031492	nucleosomal DNA binding
GO:0042802	identical protein binding
GO:0048156	tau protein binding
GO:0050998	nitric-oxide synthase binding
GO:0098973	structural constituent of postsynaptic actin cytoskeleton

	Biological Process
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001738	morphogenesis of a polarized epithelium
GO:0006338	chromatin remodeling
GO:0006357	regulation of transcription by RNA polymerase II
GO:0007010	cytoskeleton organization
GO:0007163	establishment or maintenance of cell polarity
GO:0007409	axonogenesis
GO:0008284	positive regulation of cell population proliferation
GO:0021762	substantia nigra development
GO:0022898	regulation of transmembrane transporter activity
GO:0030071	regulation of mitotic metaphase/anaphase transition
GO:0032091	negative regulation of protein binding
GO:0034333	adherens junction assembly
GO:0035633	maintenance of blood-brain barrier
GO:0042981	regulation of apoptotic process
GO:0045176	apical protein localization
GO:0045582	positive regulation of T cell differentiation
GO:0045596	negative regulation of cell differentiation
GO:0045597	positive regulation of cell differentiation
GO:0045663	positive regulation of myoblast differentiation
GO:0045893	positive regulation of DNA-templated transcription
GO:0048870	cell motility
GO:0051621	regulation of norepinephrine uptake
GO:0051623	positive regulation of norepinephrine uptake
GO:0051726	regulation of cell cycle
GO:0070316	regulation of G0 to G1 transition
GO:0070527	platelet aggregation
GO:0071896	protein localization to adherens junction
GO:0072749	cellular response to cytochalasin B
GO:0098974	postsynaptic actin cytoskeleton organization
GO:0150111	regulation of transepithelial transport
GO:1900242	regulation of synaptic vesicle endocytosis
GO:1902459	positive regulation of stem cell population maintenance
GO:1903076	regulation of protein localization to plasma membrane
GO:1905168	positive regulation of double-strand break repair via homologous recombination
GO:2000045	regulation of G1/S transition of mitotic cell cycle
GO:2000779	regulation of double-strand break repair
GO:2000781	positive regulation of double-strand break repair
GO:2000819	regulation of nucleotide-excision repair

	Cellular Component
GO:0000776	kinetochore
GO:0000785	chromatin
GO:0000786	nucleosome
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0005903	brush border
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0005925	focal adhesion
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0016363	nuclear matrix
GO:0016514	SWI/SNF complex
GO:0016586	RSC-type complex
GO:0030027	lamellipodium
GO:0030424	axon
GO:0030863	cortical cytoskeleton
GO:0031982	vesicle
GO:0032991	protein-containing complex
GO:0035060	brahma complex
GO:0035267	NuA4 histone acetyltransferase complex
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0043296	apical junction complex
GO:0044305	calyx of Held
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:0070160	tight junction
GO:0071564	npBAF complex
GO:0071565	nBAF complex
GO:0072562	blood microparticle
GO:0097433	dense body
GO:0098685	Schaffer collateral - CA1 synapse
GO:0098793	presynapse
GO:0098871	postsynaptic actin cytoskeleton
GO:0098978	glutamatergic synapse
GO:0140092	bBAF complex
GO:0140288	GBAF complex
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8rtt, PDBe:8rtt, PDBj:8rtt
PDBsum	8rtt
PubMed	38603491
UniProt	P60709\|ACTB_HUMAN Actin, cytoplasmic 1 (Gene Name=ACTB)

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