Structure of PDB 8rcn Chain B

Receptor sequence

>8rcnB (length=1521) Species: 9606 (Homo sapiens) [Search protein sequence]

ILKALILKLKDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDML
QDSSLLAKRQVALWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQ
GTRREAIRVLGLLGALDPYKHKVNIEMLVNMGNLPLDEFYPAVSMVALMR
IFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGA
IREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIE
QIVVALGGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLAAIQLFGANL
DDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRLTESLDFTDYASRIIH
PIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQ
RYDVLICRIVKGYTLSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDS
SSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELAL
TSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAK
ALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFGARMA
AAAAWGLSMEEYTCMIPRDTHDGAFYRALALHQDLFSLAQQCIDKARDLL
DAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWE
RLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHK
TLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFV
QTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPK
VLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKVTEDL
SKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEAL
VEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALI
YPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILW
HEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQA
YGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLEL
QYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLT
LMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQ
RYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAP
DYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRS
LAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPE
KIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVY
DPLLNWRLMDTNTALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELL
IKQATSHENLCQCYIGWCPFW

3D structure

PDB

8rcn CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, Focused region of mTOR and RAPTOR on one protomer copy.

Chain

Resolution

3.1 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ANP	B	K2187 E2190 W2239 V2240	K1214 E1217 W1266 V1267
BS02	MG	B	T2245 P2341 S2342 N2343 L2344	T1272 P1368 S1369 N1370 L1371

External links

PDB	RCSB:8rcn, PDBe:8rcn, PDBj:8rcn
PDBsum	8rcn
PubMed
UniProt	P42345\|MTOR_HUMAN Serine/threonine-protein kinase mTOR (Gene Name=MTOR)

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