Structure of PDB 8rck Chain B

Receptor sequence

>8rckB (length=2036) Species: 9606 (Homo sapiens)

TRFYDQLNHHIFELERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPS
NDPVVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLEGRRHAAVLVL
RELAISVPTFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQ
RWYRHTFEEAEKGFIHGALLILNELVRISSMEGERLREEMEEISLIQMTI
LNLLPRLAAFRPTQYLQDTMNHVLSCERTAAFQALGLLSVAVRSEFKVYL
PRVLDIIRAALPPKVDATVFTCISMLARIQQDIKELLEPMLAVGLSPALT
AVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHDVGSITLALRTLGSFEFEL
TQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSVSQTAVQVVADVLSKL
LVVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRE
LAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGH
LVSNAPRLIRPYMEPILKALILKLKDPNPGVINNVLATIGELAQVSGLEM
RKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYRKYPT
LLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIEMLVNMGNLP
LDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQ
VMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFW
VMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSPGRIV
SIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRL
TESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFI
PMVNKVLVRHRINHQRYDVLICRIVKGYTLSTINLQKAWGAARRVSKDDW
LEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELN
EDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAA
GVLEYAMKHFGARMAAAAAWGLSMEEYTCMIPRDTHDGAFYRALALHQDL
FSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYK
LVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKY
ASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWK
SARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGE
WQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKH
QNQARDEKKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLT
LWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIH
QLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQ
AMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMM
ERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVF
RRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAP
SLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTL
LANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKK
ILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSP
SSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDF
GDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLR
EHKDSVMAVLEAFVYDPLLNWRLMDTNTALNKKAIQIINRVRDKLTGRDF
SHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPFW

3D structure

• PDB: 8rck CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, Focused on one protomer copy.
• Chain: B
• Resolution: 3.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ANP	B	Q2167 W2239 V2240 D2357	Q1709 W1781 V1782 D1899
BS02	MG	B	K2187 E2190	K1729 E1732

External links

• PDB: RCSB:8rck, PDBe:8rck, PDBj:8rck
• PDBsum: 8rck
• UniProt: P42345|MTOR_HUMAN Serine/threonine-protein kinase mTOR (Gene Name=MTOR)