Structure of PDB 8rcd Chain B

Receptor sequence

>8rcdB (length=310) Species: 9606 (Homo sapiens) [Search protein sequence]

GPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAK
ADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETG
SITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPER
LLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLI
VDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVV
AQVPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAI
NADGVGDAKD

3D structure

PDB

8rcd RAD51 protects abasic sites to prevent replication fork breakage.

Chain

Resolution

3.2 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	B	R229 R241 Q242 V270 A271 V273 K285 I287 G288 G289 N290	R209 R221 Q222 V250 A251 V253 K256 I258 G259 G260 N261
BS02	ATP	B	F129 R130 G132 K133 T134 Q135 R170 R310 I329	F109 R110 G112 K113 T114 Q115 R150 R281 I300
BS03	CA	B	T134 E163	T114 E143
BS04	CA	B	A293 H294 S296 D316	A264 H265 S267 D287
BS05	ATP	B	H294 S317 P318 C319 L320 P321	H265 S288 P289 C290 L291 P292

External links

PDB	RCSB:8rcd, PDBe:8rcd, PDBj:8rcd
PDBsum	8rcd
PubMed	39178838
UniProt	Q06609\|RAD51_HUMAN DNA repair protein RAD51 homolog 1 (Gene Name=RAD51)

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