Structure of PDB 8rbx Chain B

Receptor sequence
>8rbxB (length=1112) Species: 9823 (Sus scrofa) [Search protein sequence]
DDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAP
PIDLQPPRYLLKFEQIYLSKPTHWDGAPSPMMPNEARLRNLTYSAPLYVD
ITKTVQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGG
YFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTS
TIWVSMLARQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFED
PEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQ
KEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLD
LAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGL
KYSLATGNWGDARAGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQ
LHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSM
ENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNN
YSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHP
SMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHV
LYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSA
VDRGFFRSVFYRSYKEQESKKQEEVFEKPTRETCQGMRHAIYDKLDDDGL
IAPGVRVSGDDVIIGKTVTLPERRYTKRDCSTFLRTSETGIVDQVMVTLN
QEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGIT
PDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKIS
NLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSR
ARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASD
PYQVHVCNLCGIMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQEL
MSMSIAPRMMSV
3D structure
PDB8rbx Structural basis of Integrator-dependent RNA polymerase II termination
ChainB
Resolution4.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B Q468 R491 Q731 G839 R841 K934 K942 H1053 R1080 Q418 R441 Q681 G786 R788 K872 K880 H991 R1018
BS02 dna B T746 R812 R897 G1077 R1078 S1079 L1084 R1085 M1089 T696 R762 R835 G1015 R1016 S1017 L1022 R1023 M1027
BS03 ZN B C1119 C1137 C1057 C1075
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rbx, PDBe:8rbx, PDBj:8rbx
PDBsum8rbx
PubMed38570683
UniProtI3LGP4

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