Structure of PDB 8r65 Chain B

Receptor sequence
>8r65B (length=718) Species: 88776 (Influenza A virus (A/Brevig Mission/1/1918(H1N1))) [Search protein sequence]
MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYS
EKGRWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP
GIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RSNGLTANESGRLIDFLKDVMESMDKEEMEITTHFGKKKQRLNKRSYLIR
ALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSG
LPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLA
MITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPA
EMLASIDLKYFNDSTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLG
VSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTC
KLLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINES
ADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQT
RRSFEIKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDY
QGRLCNPLNPFVSHKEMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQM
YQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKE
EFAEIMKICSTIEELRRQ
3D structure
PDB8r65 1918 H1N1 Viral polymerase heterotrimer in complex with 4 repeat serine-5 phosphorylated PolII peptide with ordered PB2 C-terminal domains
ChainB
Resolution4.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B H32 T34 Y355 M356 R365 H32 T34 Y335 M336 R345
BS02 rna B N671 R672 S673 N676 N633 R634 S635 N638
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8r65, PDBe:8r65, PDBj:8r65
PDBsum8r65
PubMed
UniProtQ3HM40|RDRP_I18A0 RNA-directed RNA polymerase catalytic subunit (Gene Name=PB1)

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