Structure of PDB 8r5q Chain B

Receptor sequence
>8r5qB (length=318) Species: 9606 (Homo sapiens) [Search protein sequence]
LIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWE
LDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALD
FNDFREYLSPASGFQSLQFRLLENKIGVLQFKGEENELLLKSEQEKTLLE
LVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQ
VAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPR
FQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGRYKVFVDLFNLSTYLI
PRHWIPKMNPTIHKFLEH
3D structure
PDB8r5q Discovery and binding mode of a small molecule inhibitor of the apo form of human TDO2
ChainB
Resolution2.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.13.11.11: tryptophan 2,3-dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y5N B Y42 Y45 L46 Y3 Y6 L7
BS02 Y5N B F72 H76 F140 P149 G152 Q154 S155 H328 V332 M335 F33 H37 F101 P110 G113 Q115 S116 H275 V279 M282
BS03 ZIQ B R103 E105 W208 R211 P213 F304 R64 E66 W155 R158 P160 F251
Gene Ontology
Molecular Function
GO:0004833 tryptophan 2,3-dioxygenase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0019441 tryptophan catabolic process to kynurenine

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Molecular Function
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Biological Process
External links
PDB RCSB:8r5q, PDBe:8r5q, PDBj:8r5q
PDBsum8r5q
PubMed
UniProtP48775|T23O_HUMAN Tryptophan 2,3-dioxygenase (Gene Name=TDO2)

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