Structure of PDB 8r4v Chain B

Receptor sequence
>8r4vB (length=316) Species: 9606 (Homo sapiens) [Search protein sequence]
ARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKI
FREVQIMKMLSHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRM
AEKEARRKFKQIVTAVYFCHSRNIVHRDLKAENLLLDANLNIKIADFGFS
NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGA
LPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQ
ICKHKWMKLGDADPNFDRLIAESQQPLNEDVLLAMEDMGLDKEQTLQSLR
SDAYDHYSAIYSLLCD
3D structure
PDB8r4v The structures of salt inducible kinase 3 in complex with pharmacological inhibitors reveal determinants for binding and selectivity.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XWA B I72 V80 A93 K95 L140 T142 Y144 A145 G148 E149 D152 L195 A205 I12 V20 A33 K35 L80 T82 Y84 A85 G88 E89 D92 L135 A145
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8r4v, PDBe:8r4v, PDBj:8r4v
PDBsum8r4v
PubMed38508313
UniProtQ9Y2K2|SIK3_HUMAN Serine/threonine-protein kinase SIK3 (Gene Name=SIK3)

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