Structure of PDB 8r3r Chain B

Receptor sequence
>8r3rB (length=658) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
MSNLSVNAIRFLGIDAINKANSGHPGVVMGAAPMAYSLFTKQLHINPAQP
NWINRDRFILSAGHGSMLLYALLHLSGFEDVSMDEIKSFRQWGSKTPGHP
EFGHTAGIDATTGPLGQGISTATGFAQAERFLAAKYNREGYNIFDHYTYV
ICGDGDLMEGVSSEAASYAGLQKLDKLVVLYDSNDINLDGETKDSFTESV
RDRYNAYGWHTALVENGTDLEAIHAAIETAKASGKPSLIEVKTVIGYGSP
NKQGTNAVHGAPLGADETASTRQALGWDYEPFEIPEQVYADFKEHVADRG
ASAYQAWTKLVADYKEAHPELAAEVEAIIDGRDPVEVTPADFPALENGFS
QATRNSSQDALNVVAAKLPTFLGGSADLAHSNMTYIKTDGLQDDANRLNR
NIQFGVREFAMGTILNGMALHGGLRVYGGTFFVFSDYVKAAVRLSALQGL
PVTYVFTHDSIAVGEDGPTHEPVEHLAGLRAMPNLNVFRPADARETQAAW
YLAVTSEKTPTALVLTRQNLTVEDGTDFDKVAKGAYVVYENAADFDTILI
ATGSEVNLAVSAAKELASQGEKIRVVSMPSTDVFDKQDAAYKEEILPNAV
RRRVAVEMGASQNWYKYVGLDGAVLGIDTFGASAPAPKVLAEYGFTVENL
VKVVRNLK
3D structure
PDB8r3r Are Transketolases relevant Targets fighting Human Pathogens? A comparative Biochemical, Bioinformatic and Structural Study
ChainB
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.2.1.1: transketolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPP B E408 F434 Y437 E408 F434 Y437
BS02 TPP B H64 L115 D154 G155 N184 I186 H259 H64 L115 D154 G155 N184 I186 H259
BS03 MG B D154 N184 I186 D154 N184 I186
Gene Ontology
Molecular Function
GO:0004802 transketolase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006098 pentose-phosphate shunt
GO:0006310 DNA recombination
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8r3r, PDBe:8r3r, PDBj:8r3r
PDBsum8r3r
PubMed
UniProtP22976|TKT_STRPN Probable transketolase (Gene Name=tkt)

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