Structure of PDB 8r3p Chain B

Receptor sequence

>8r3pB (length=666) Species: 1352 (Enterococcus faecium)

MFDKIDQLGVNTIRTLSIEAVQKANSGHPGLPMGAAPMAYALWTKHLKVN
PTTSKNWADRDRFVLSAGHGSAMLYSLLHLAGYQVTIDDLKQFRQWDSKT
PGHPEVHHTDGVEATTGPLGQGIAMAVGMAMAEAHLAATYNKENFNVMDH
YTYAICGDGDLMEGVSQEASSMAGHMKLGKLIVLYDSNDISLDGPTSKAF
TENVGARYEAYGWQHILVKDGNDLEAISKAIEEAKAETDKPTLIEVKTVI
GYGAPKEGTSAVHGAPLGEDGIKMAKEVYGWEYPDFTVPEEVAARFHQTM
IEEGQKAEDAWNEMFANYKKAYPELAQQFEDAFDGKLPENWDAELPTYEV
GSSQASRVSSKEVIQELSKAIPSFWGGSADLSGSNNTMVAADKDFTPEHY
EGRNIWFGVREFAMASAMNGIQLHGGTRIYGGTFFVFVDYLRPAVRLAAI
QHTPVVYVLTHDSVAVGEDGPTHEPIEQLASVRCMPGVQVIRPADGNETR
AAWKVAMETTDAPTILVLSRQNLPVLPSTKEVADEMVKKGAYVLSPSQGE
TPEGILIATGSEVDLAVKAQKELAEKGKDVSVVSMPSFDLFEKQSSEYKE
SVLPKSVKKRVAIEAAASFGWERYVGTEGATITIDHFGASAPGTKILEEF
GFTVENVVNTYNQLSE

3D structure

• PDB: 8r3p Are Transketolases relevant Targets fighting Human Pathogens? A comparative Biochemical, Bioinformatic and Structural Study
• Chain: B
• Resolution: 2.9 Å

Enzymatic activity

• Enzyme Commision number: 2.2.1.1: transketolase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TPP	B	D380 E411 F437 Y440	D380 E411 F437 Y440
BS02	TPP	B	H69 L119 D158 G159 N188 I190 S191 L192 I250 H263	H69 L119 D158 G159 N188 I190 S191 L192 I250 H263
BS03	MG	B	D158 N188 I190	D158 N188 I190

Gene Ontology

Molecular Function

• GO:0004802 transketolase activity
• GO:0016740 transferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006098 pentose-phosphate shunt

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:8r3p, PDBe:8r3p, PDBj:8r3p
• PDBsum: 8r3p
• UniProt: A0A133CKH8