Structure of PDB 8r32 Chain B

Receptor sequence
>8r32B (length=252) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RSLIVTTILEEPYVLFKKSLYGNDRFEGYCIDLLRELSTILGFTYEIRLV
EDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPF
MTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYD
KMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLT
QIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG
CP
3D structure
PDB8r32 The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2.
ChainB
Resolution1.6 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU B Y488 P516 A518 R523 G688 A689 T690 E738 Y55 P83 A85 R90 G135 A136 T137 E185
BS02 2J9 B P532 S761 K762 G763 P99 S208 K209 G210
External links
PDB RCSB:8r32, PDBe:8r32, PDBj:8r32
PDBsum8r32
PubMed38369668
UniProtP42260|GRIK2_RAT Glutamate receptor ionotropic, kainate 2 (Gene Name=Grik2)

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