Structure of PDB 8qz8 Chain B

Receptor sequence

>8qz8B (length=512) Species: 1549864 (Tilapia lake virus)

MWAFQEGVCKGNLLSGPTSMKAPDSAARESIDRASEIMTGKSYNAVHTGD
LSKLPNQGESPLRIVDSDLYSERSCCWVIEKEGRVVCKSTTLTRGMTSLL
NTTKCSSPSELICKVLTVESLSEKIGDTSVEELLSHGRYFKCALRDQERG
KPKSRAIFLSHPFFRLLSSVVETHARSVLSKVSAVYTATASAEQRAMMAA
QVVESRKHVLNGDCTKYNEAIDADTLLKVWDAIGMGSIGVMLAYMVRRKC
VLIKDTLVECPGGMLMGMFNATATLALQGTTDRFLSFSDDFITSFNSPAE
LREIEDLLFASCHNLSLKKSYISVASLEINSCTLTRDGDLATGLGCTAGV
PFRGPLVTLKQTAAMLSGAVDSGVMPFHSAERLFQIKQQECAYRYNNPTY
TTRNEDFLPTCLGGKTVISFQSLLTWDCHPFWYQVHPDGPDTIDQKVLSV
LASKTRRTRLEALSDLDPLVPHRLLVSESDVSKIRAARQAHLKSLGLEQP
TNFNYAIYKAVQ

3D structure

• PDB: 8qz8 Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.
• Chain: B
• Resolution: 3.13 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	B	R73 S74 S89 L144 R145 D146 I157 F158 L159 R165 T189 S191 R394 N397 T399 D438 K454 R487 Q501 N504	R73 S74 S89 L144 R145 D146 I157 F158 L159 R165 T189 S191 R394 N397 T399 D438 K454 R485 Q499 N502
BS02	rna	B	K10 S67 R149 D289 D290 N330 S331 Q361	K10 S67 R149 D289 D290 N330 S331 Q361
BS03	G2P	B	K151 R155 T215 K216 N218 D289	K151 R155 T215 K216 N218 D289
BS04	MG	B	D213 D290 E328	D213 D290 E328

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0001172 RNA-templated transcription

External links

• PDB: RCSB:8qz8, PDBe:8qz8, PDBj:8qz8
• PDBsum: 8qz8
• PubMed: 38066000
• UniProt: A0A1Y9SHW4