Structure of PDB 8qyu Chain B

Receptor sequence
>8qyuB (length=756) Species: 9913 (Bos taurus) [Search protein sequence]
DAEMAAFGEAAPYLRKSEKERLEAQTRPFDLKKDVFVPDDKEEFVKATIL
SRGKVTAETKTVTVKEDQVLQQNPPKFDKIEDMAMLTFLHEPAVLYNLKE
RYASWMIYTYSGLFCVTINPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSI
SDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAITLEDQI
IQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEK
SRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTV
ASIDDAEELMATDNAFDVLGFTTEEKNSMYKLTGAIMHFGNMKFKLQAEP
DGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVVYAKG
ALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQ
LCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIE
KPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSSNFQKPRNIKGKPEA
HFSLIHYAGTVDYNIIGWLQKNKDPLNETVVDLYKKSSLKMLSSLFATVS
ALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVIDNPLVMHQLRCNGV
LEGIRICRKGFPNRILYGDFRQRYRILNPAAIPQFIDSRKGAEKLLGSLD
IDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLSRME
FKKLLE
3D structure
PDB8qyu Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction.
ChainB
Resolution1.96 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B N126 P127 G181 G183 K184 T185 V186 N238 N119 P120 G174 G176 K177 T178 V179 N218
BS02 MG B T185 S242 T178 S222
BS03 2OW B K146 Y164 T167 D168 H666 P710 N711 R712 Y722 K139 Y157 T160 D161 H618 P662 N663 R664 Y674
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8qyu, PDBe:8qyu, PDBj:8qyu
PDBsum8qyu
PubMed38014327
UniProtQ9BE39|MYH7_BOVIN Myosin-7 (Gene Name=MYH7)

[Back to BioLiP]