Structure of PDB 8qyr Chain B

Receptor sequence
>8qyrB (length=711) Species: 9913 (Bos taurus) [Search protein sequence]
KKDVFVPDDKEEFVKATILSREGGKVTAETEHGKTVTVKEDQVLQQNPPK
FDKIEDMAMLTFLHEPAVLYNLKERYASWMIYTYSGLFCVTINPYKWLPV
YNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAG
KTVNTKRVIQYFAVIAAIGGKGTLEDQIIQANPALEAFGNAKTVRNDNSS
RFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSN
KKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDVLGFT
TEEKNSMYKLTGAIMHFGNMKFKLKEQAEPDGTEEADKSAYLMGLNSADL
LKGLCHPRVKVGNEYVTKGQNVQQVVYAKGALAKAVYERMFNWMVTRINA
TLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFV
LEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATD
MTFKAKLFDNHLGKSSNFQKPRKPEAHFSLIHYAGTVDYNIIGWLQKNKD
PLNETVVDLYKKSSLKMLSSLFANYAFQTVSALHRENLNKLMTNLRSTHP
HFVRCIIPNETKSPGVIDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGD
FRQRYRILNPAAIPDIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLL
GLLEEMRDERL
3D structure
PDB8qyr Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XB2 B Y164 T167 D168 H666 N711 R712 I713 R721 E774 Y131 T134 D135 H599 N644 R645 I646 R654 E704
BS02 MG B T185 S242 T152 S200
BS03 ADP B N126 P127 G181 G183 K184 T185 V186 N238 N93 P94 G148 G150 K151 T152 V153 N196
BS04 BEF B S180 K184 N238 S241 S242 G464 S147 K151 N196 S199 S200 G419
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:8qyr, PDBe:8qyr, PDBj:8qyr
PDBsum8qyr
PubMed38014327
UniProtQ9BE39|MYH7_BOVIN Myosin-7 (Gene Name=MYH7)

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