Structure of PDB 8qru Chain B

Receptor sequence

>8qruB (length=415) Species: 9606 (Homo sapiens) [Search protein sequence]

LRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLR
LLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVG
LALALQPGAASKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYEERVKVPV
GQEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSW
IMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLP
LIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAK
HISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTAT
ASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNV
EGDALGAGLLQNYVD

3D structure

PDB

8qru Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2.

Chain

Resolution

2.9 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GLN	B	S351 S352 S353 A390 G430 I431 G434 G435 D464 C467 T468 N471	S279 S280 S281 A318 G358 I359 G362 G363 D392 C395 T396 N399

External links

PDB	RCSB:8qru, PDBe:8qru, PDBj:8qru
PDBsum	8qru
PubMed	39095408
UniProt	Q15758\|AAAT_HUMAN Neutral amino acid transporter B(0) (Gene Name=SLC1A5)

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