Structure of PDB 8qn0 Chain B

Receptor sequence
>8qn0B (length=317) Species: 9606 (Homo sapiens) [Search protein sequence]
PLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRY
QIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGL
SQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIK
VFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLF
VNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKS
LGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMD
KPTEVNQILIKWLDSDA
3D structure
PDB8qn0 Photosensitization enables Pauson-Khand-type reactions with nitrenes.
ChainB
Resolution1.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.76: lipid-phosphate phosphatase.
3.3.2.10: soluble epoxide hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WJ5 B D335 W336 M339 F381 Y383 M419 Y466 L499 M503 H524 D109 W110 M113 F152 Y154 M190 Y237 L270 M274 H295
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:8qn0, PDBe:8qn0, PDBj:8qn0
PDBsum8qn0
PubMed38301027
UniProtP34913|HYES_HUMAN Bifunctional epoxide hydrolase 2 (Gene Name=EPHX2)

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