Structure of PDB 8qel Chain B

Receptor sequence
>8qelB (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
AHTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKA
EREVKALAKLDHVNIVHYNGCWDGFDYDPETSSKTKCLFIQMEFCDKGTL
EQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFLVD
TKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYAL
GLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPE
DRPNTSEILRTLTVWKK
3D structure
PDB8qel PKR kinase domain- eIF2alpha in complex with compound
ChainB
Resolution2.451 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UH3 B V294 K296 M366 C369 F421 G431 D432 V39 K41 M92 C95 F147 G157 D158
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8qel, PDBe:8qel, PDBj:8qel
PDBsum8qel
PubMed
UniProtP19525|E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase (Gene Name=EIF2AK2)

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