Structure of PDB 8q9w Chain B

Receptor sequence
>8q9wB (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
SRIFYLRNFNNWMKSVLIGEFLEKVRQKKKRDITVLDLGCGKGGDLLKWK
KGRINKLVCTDIADVSVKQCQQRYEDMKNRRDSEYIFSAEFITADSSKEL
LIDKFRDPQMCFDICSCQFVCHYSFESYEQADMMLRNACERLSPGGYFIG
TTPNSFELIRRLEASETESFGNEIYTVKFQKKGDYPLFGCKYDFNLEGVV
DVPEFLVYFPLLNEMAKKYNMKLVYKKTFLEFYEEKIKNNENKMLLKRMG
LGCLSKSEWEATSIYLVFAFEKQQ
3D structure
PDB8q9w Structure-Guided Design of HsRNMT inhibitors
ChainB
Resolution2.5 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SFG B G205 C206 D227 I228 D261 G39 C40 D61 I62 D95
BS02 GNP B N176 H288 Y289 F360 E370 Y467 N10 H122 Y123 F194 E204 Y265
External links
PDB RCSB:8q9w, PDBe:8q9w, PDBj:8q9w
PDBsum8q9w
PubMed
UniProtO43148|MCES_HUMAN mRNA cap guanine-N7 methyltransferase (Gene Name=RNMT)

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