Structure of PDB 8q43 Chain B

Receptor sequence
>8q43B (length=428) Species: 509193 (Thermoanaerobacter brockii subsp. finnii Ako-1) [Search protein sequence]
MNEKVLVLIVGTNPLPNYVVGSHLKEKYDKFVLIYSEKNDKINQNSTYDY
AKKLKEHLNLNDKCIFLPLSDVSNSEKIINDLREKFPSEDFVEVHLNYTG
GTKTMVVHIYNFLKEKFKFEGSYLDARDYKLVYDYSEEAISLKDTIKIDI
NTLLSIHLYEDIHFEFYDTYSYKQKFVDSFDKISQEIEKAIKDDKGEDFV
KWLEDPFRKIFKGENKLLEKTAKFKKHIEKLDSSPIVKFNEKTPQFIWDI
LNAFPEGKKLNDGQKLWIPDDKITNDNLSSRVKDTVEFLNGKWFEWYVYS
QIKSELLDRKLKEGEHFGISLKAQKKDSPYFALDIFLINGYQLIGISLTT
SSTRELCKLKGFEVIHRVRQIGGDESKAILITGMDKSKTEDLQKDLAYET
GSTQKRFVVFGIDDWADIGSKICEEVFK
3D structure
PDB8q43 Substrate selectivity and catalytic activation of the type III CRISPR-associated ancillary nuclease Can2
ChainB
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B R213 K217 E296 N299 K301 Y339 A341 T358 T359 S360 R208 K212 E287 N290 K292 Y330 A332 T349 T350 S351
BS02 rna B T12 P16 S36 T47 T99 G101 T102 K103 Y128 A131 R132 E384 T409 G410 T12 P16 S36 T47 T99 G101 T102 K103 Y123 A126 R127 E375 T400 G401
BS03 MN B D343 L357 D334 L348
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:8q43, PDBe:8q43, PDBj:8q43
PDBsum8q43
PubMed38033326
UniProtE8URK0

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