Structure of PDB 8q40 Chain B

Receptor sequence
>8q40B (length=437) Species: 509193 (Thermoanaerobacter brockii subsp. finnii Ako-1) [Search protein sequence]
MNEKVLVLIVGTNPLPNYVVGSHLKEKYDKFVLIYSEKNDKINQNSTYDY
AKKLKEHLNLNDKCIFLPLSDVSNSEKIINDLREKFPSEDFVEVHLNYTG
GTKTMVVHIYNFLKEKFKNNKIKFEGSYLDARDYKLVYDYSEEAISLKDT
IKIDINTLLSIHLYEDIHFEFYDTYSYKQKFVDSFDKISQEIEKAIKDDK
GEDFVKWLEDPFRKIFKGENKLLEKTAKFKKHIEKLLKDNDSSPIVKFNE
KTPQFIWDILNAFPEGKKLNDGQKLWIPDDKITNDNLSSRVKDTVEFLNG
KWFEWYVYSQIKSELLDRKLKEGEHFGISLKAQKKDSPYFELDIFLINGY
QLIGISLTTSSTRELCKLKGFEVIHRVRQIGGDESKAILITGMDKSKTED
LQKDLAYETGSTQKRFVVFGIDDWADIGSKICEEVFK
3D structure
PDB8q40 Substrate selectivity and catalytic activation of the type III CRISPR-associated ancillary nuclease Can2
ChainB
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B E209 R213 N299 K301 T358 T359 L365 E209 R213 N299 K301 T358 T359 L365
BS02 rna B G11 T12 N13 P16 S36 T47 T99 G101 T102 K103 Y128 A131 E384 G410 G11 T12 N13 P16 S36 T47 T99 G101 T102 K103 Y128 A131 E384 G410
BS03 MN B E341 D343 E341 D343
BS04 MN B D343 L357 D343 L357
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:8q40, PDBe:8q40, PDBj:8q40
PDBsum8q40
PubMed38033326
UniProtE8URK0

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