Structure of PDB 8q26 Chain B

Receptor sequence

>8q26B (length=393) Species: 9606 (Homo sapiens) [Search protein sequence]

GPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLP
QGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRP
PGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKK
LRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNP
RKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLL
TRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTL
PSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNAL
DLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ

3D structure

PDB

8q26 HsNMT1 in complex with both MyrCoA and GNCFSKPR inhibitor peptide

Chain

Resolution

1.9 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	V181 D183 D185 F188 F190 T282 G284 Y296 H298 F311 S405 I469 G470 D471 G472 N473 Q496	V78 D80 D82 F85 F87 T179 G181 Y193 H195 F208 S302 I366 G367 D368 G369 N370 Q393
BS02	COA	B	R115 Y117 Q118 F119 W120 Y180 V181 L248 C249 V250 R255 S256 R258 A260 P261 A283	R12 Y14 Q15 F16 W17 Y77 V78 L145 C146 V147 R152 S153 R155 A157 P158 A180

External links

PDB	RCSB:8q26, PDBe:8q26, PDBj:8q26
PDBsum	8q26
PubMed
UniProt	P30419\|NMT1_HUMAN Glycylpeptide N-tetradecanoyltransferase 1 (Gene Name=NMT1)

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