Structure of PDB 8q0u Chain B

Receptor sequence
>8q0uB (length=273) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
QIDGFVRTLRARPEAGGKVPVFVFHPAGGSTVVYEPLLGRLPADTPMYGF
ERVEGSIEERAQQYVPKLIEMQGDGPYVLVGWSLGGVLAYACAIGLRRLG
KDVRFVGLIDAVRAGEEIPQTKEEIRKRWDRYAAFAEKTIPAIPYEQLEE
LDDEGQVRFVLDAVSQSGVQIPAGIIEHQRTSYLDNRAIDTAQIQPYDGH
VTLYMADRYHDDAIMFEPRYAVRQPDGGWGEYVSDLEVVPIGGEHIQAID
EPIIAKVGEHMSRALGQIEADRT
3D structure
PDB8q0u Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IKG B S1533 V1537 A1561 V1562 R1563 N1640 I1643 I1648 Y1663 H1664 A1667 F1670 Y1674 W1683 H1699 S83 V87 A111 V112 R113 N186 I189 I194 Y209 H210 A213 F216 Y220 W229 H245
Gene Ontology
Biological Process
GO:0009058 biosynthetic process

View graph for
Biological Process
External links
PDB RCSB:8q0u, PDBe:8q0u, PDBj:8q0u
PDBsum8q0u
PubMed37948640
UniProtI6X8D2|PKS13_MYCTU Polyketide synthase Pks13 (Gene Name=pks13)

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