Structure of PDB 8q0n Chain B

Receptor sequence
>8q0nB (length=831) Species: 9606 (Homo sapiens) [Search protein sequence]
ELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYAFGRVKRSLLHI
AANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYS
ADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVA
CQNGHKTTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGA
KYLPDKNGVTPLDLCVQGGYGETCEVLIQYHPRLFQTIIQMTQNEDLREN
MLRQVLEHLSQQSESQYLKILTSLAEVATTNGHKLLSLSSNYDAQMKSLL
RIVRMFCHVFRIGPSSPNKTPRSQVFKPLELLWHSLDEWLVLIATELMKN
KRDSTEITSILLKQASADCQDVISMTANRLSAVIQAFYMCCSCQMPPGMT
SPRFIEFVCKHDEVLKCFVNRNPKIIFDHFHFLLECPELMSRFMHIIKAQ
PFKDRCEWFYEHLHSGQPDSDMVHRPVNENDILLVHRDSIFRSSCEVVSK
ANCAKLKQGIAVRFHGEEGMGQGVVREWFDILSNEIVNPDYALFTQSADG
TTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG
IPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVP
LKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSL
IQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVED
ITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPT
SSTCINMLKLPEYPSKEILKDRLLVALHCGS
3D structure
PDB8q0n Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1
ChainB
Resolution4.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 04E B Q594 C876 Q522 C804
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0031267 small GTPase binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007030 Golgi organization
GO:0016567 protein ubiquitination
GO:0016601 Rac protein signal transduction
GO:0030334 regulation of cell migration
GO:0061025 membrane fusion
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016604 nuclear body
GO:0032580 Golgi cisterna membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8q0n, PDBe:8q0n, PDBj:8q0n
PDBsum8q0n
PubMed38332367
UniProtQ8IYU2|HACE1_HUMAN E3 ubiquitin-protein ligase HACE1 (Gene Name=HACE1)

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