Structure of PDB 8pvm Chain B

Receptor sequence

>8pvmB (length=572) Species: 1501 (Clostridium pasteurianum) [Search protein sequence]

KTIIINGVQFNTDEDTTILKFARDNNIDISALCFLNNCNNDINKCEICTV
EVEGTGLVTACDTLIEDGMIINTNSDAVNEKIKSRISQLLDIHEFKCGPC
NRRENCEFLKLVIKYKARASKPFLPKDKTEYVDERSKSLTVDRTKCLLCG
RCVNACGKNTETYAMKFLNKNGKTIIGAEDEKCFDDTNCLLCGQCIIACP
VAALSEKSHMDRVKNALNAPEKHVIVAMAPSVRASIGELFNMGFGVDVTG
KIYTALRQLGFDKIFDINFGADMTIMEEATELVQRIENNGPFPMFTSDCP
GWVRQAENYYPELLNNLSSAKSPQQIFGTASKTYYPSISGLDPKNVFTVT
VMPCTSKKFEADRPQMEKDGLRDIDAVITTRELAKMIKDAKIPFAKLEDS
EADPAMGEYSGAGAIFGATGGVMEAALRSAKDFAENAELEDIEYKQVRGL
NGIKEAEVEINNNKYNVAVINGASNLFKFMKSGMINEKQYHFIEVMACHG
GCVNGGGQPHVNPKDLEKVDIKKVRASVLYNQDEHLSKRKSHENTALVKM
YQNYFGKPGEGRAHEILHFKYK

3D structure

PDB

8pvm Insights into the Molecular Mechanism of Formaldehyde Inhibition of [FeFe]-Hydrogenases

Chain

Resolution

1.38 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.12.7.2: ferredoxin hydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	402	B	A230 P231 S232 D299 P324 Q325 M353 P354 K358 F417 M497 C503	A229 P230 S231 D298 P323 Q324 M352 P353 K357 F416 M496 C502
BS02	SF4	B	C300 C355 A498 C499 C503	C299 C354 A497 C498 C502
BS03	SF4	B	C157 T161 T163 M166 C190 L191 L192 C193 G194 C196	C156 T160 T162 M165 C189 L190 L191 C192 G193 C195
BS04	SF4	B	C147 L148 L149 C150 G151 C153 I177 C200 P201 A204 L205	C146 L147 L148 C149 G150 C152 I176 C199 P200 A203 L204
BS05	SF4	B	H94 F96 K97 C98 C101 R104 C107 V202	H93 F95 K96 C97 C100 R103 C106 V201
BS06	FES	B	A32 C34 F35 C46 E47 C49 C62	A31 C33 F34 C45 E46 C48 C61
BS07	74C	B	D299 F417	D298 F416
BS08	74C	B	N38 C39 K159	N37 C38 K158
BS09	MG	B	N40 D42	N39 D41

Gene Ontology

	Molecular Function
GO:0005506	iron ion binding
GO:0008901	ferredoxin hydrogenase activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

View graph for
Molecular Function

External links

PDB	RCSB:8pvm, PDBe:8pvm, PDBj:8pvm
PDBsum	8pvm
PubMed	37983562
UniProt	P29166\|PHF1_CLOPA Iron hydrogenase 1

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