Structure of PDB 8puy Chain B

Receptor sequence
>8puyB (length=211) Species: 9606 (Homo sapiens) [Search protein sequence]
AWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPPPLESVD
VRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGGFYGVSSQYES
LEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVN
FLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSER
GAQHHIYRLVR
3D structure
PDB8puy Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F3Y B F233 S345 V355 C380 L383 F428 F17 S110 V120 C145 L148 F193
External links
PDB RCSB:8puy, PDBe:8puy, PDBj:8puy
PDBsum8puy
PubMed38116405
UniProtQ15562|TEAD2_HUMAN Transcriptional enhancer factor TEF-4 (Gene Name=TEAD2)

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