Structure of PDB 8pta Chain B

Receptor sequence
>8ptaB (length=352) Species: 9606 (Homo sapiens) [Search protein sequence]
DNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKK
LSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYI
VMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSN
IVVKSDCTLKILDFGLATSFMMPYVVTRYYRAPEVILGMGYKENVDIWSV
GCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVE
NRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS
VDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVM
DL
3D structure
PDB8pta Tunable c-Jun N-terminal kinase (JNK) inhibitors that target a specific cysteine by a reversible covalent bond
ChainB
Resolution2.41 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CIF B A53 M108 L110 M111 A113 N114 C116 Q117 Q120 S155 L168 A47 M102 L104 M105 A107 N108 C110 Q111 Q114 S149 L162
External links
PDB RCSB:8pta, PDBe:8pta, PDBj:8pta
PDBsum8pta
PubMed
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

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