Structure of PDB 8pso Chain B

Receptor sequence

>8psoB (length=515) Species: 1549864 (Tilapia lake virus)

MWAFQEGVCKGNLLSGPTSMKAPDSAARESIDRASEIMTGKSYNAVHTGD
LSKLPNQGESPLRIVDSDLYSERSCCWVIEKEGRVVCKSTTLTRGMTSLL
NTTKCSSPSELICKVLTVESLSEKIGDTSVEELLSHGRYFKCALRDQERG
KPKSRAIFLSHPFFRLLSSVVETHARSVLSKVSAVYTATASAEQRAMMAA
QVVESRKHVLNGDCTKYNEAIDADTLLKVWDAIGMGSIGVMLAYMVRRKC
VLIKDTLVECPGGMLMGMFNATATLALQGTTDRFLSFSDDFITSFNSPAE
LREIEDLLFASCHNLSLKKSYISVASLEINSCTLTRDGDLATGLGCTAGV
PFRGPLVTLKQTAAMLSGAVDSGVMPFHSAERLFQIKQQECAYRYNNPTY
TTRNEDFLPTCLGGKTVISFQSLLTWDCHPFWYQVHPDGPDTIDQKVLSV
LASKTRRRRTRLEALSDLDPLVPHRLLVSESDVSKIRAARQAHLKSLGLE
QPTNFNYAIYKAVQP

3D structure

• PDB: 8pso Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.
• Chain: B
• Resolution: 2.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	B	R73 S74 V85 V86 C87 K88 S89 K141 A143 L144 R145 D146 I157 F158 L159 L252 D255 M266 G267 M268 N270 L448 A452 T455 R456 R457 R458 R461	R73 S74 V85 V86 C87 K88 S89 K141 A143 L144 R145 D146 I157 F158 L159 L252 D255 M266 G267 M268 N270 L448 A452 T455 R456 R457 R458 R461
BS02	rna	B	R155 D213 C214 K216 Y217 M266 G267 D289 K319	R155 D213 C214 K216 Y217 M266 G267 D289 K319
BS03	MG	B	D213 C214 D289	D213 C214 D289
BS04	MG	B	D213 D289 D290	D213 D289 D290

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0001172 RNA-templated transcription

External links

• PDB: RCSB:8pso, PDBe:8pso, PDBj:8pso
• PDBsum: 8pso
• PubMed: 38066000
• UniProt: A0A1Y9SHW4