Structure of PDB 8ppj Chain B

Receptor sequence
>8ppjB (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMSWGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVE
RDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMY
KKMLAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQ
VLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLFVH
DHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGI
LASLAER
3D structure
PDB8ppj Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity
ChainB
Resolution1.75 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.1.127: inositol-trisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B H185 F198 K209 Q249 D250 L251 K336 L401 I415 D416 H3 F9 K20 Q60 D61 L62 K132 L197 I211 D212
BS02 661 B K264 R285 M288 K291 K312 Y315 R319 K419 K75 R96 M99 K102 K108 Y111 R115 K215
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0032958 inositol phosphate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8ppj, PDBe:8ppj, PDBj:8ppj
PDBsum8ppj
PubMed38374076
UniProtP23677|IP3KA_HUMAN Inositol-trisphosphate 3-kinase A (Gene Name=ITPKA)

[Back to BioLiP]