Structure of PDB 8pph Chain B

Receptor sequence
>8pphB (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMSWVGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVV
ERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARKDMYKKMLA
VDPEAPTEEEHAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFK
TTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIG
SSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLG
LDNLIGILASLAER
3D structure
PDB8pph Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.127: inositol-trisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B H185 F198 K209 D250 L251 D262 K336 L401 I415 D416 H3 F10 K21 D62 L63 D74 K139 L204 I218 D219
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0032958 inositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8pph, PDBe:8pph, PDBj:8pph
PDBsum8pph
PubMed38374076
UniProtP23677|IP3KA_HUMAN Inositol-trisphosphate 3-kinase A (Gene Name=ITPKA)

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