Structure of PDB 8ppg Chain B

Receptor sequence
>8ppgB (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMSWVQLATGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAF
HGVVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTTKPRYMQW
REGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFEEFVQGDEE
VLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFG
KTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAER
3D structure
PDB8ppg Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity
ChainB
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.127: inositol-trisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B H185 F198 K209 Q249 D250 L251 K336 L401 I415 D416 H3 F14 K25 Q65 D66 L67 K118 L183 I197 D198
BS02 46I B K264 K312 Y315 R319 K419 K80 K94 Y97 R101 K201
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0032958 inositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ppg, PDBe:8ppg, PDBj:8ppg
PDBsum8ppg
PubMed38374076
UniProtP23677|IP3KA_HUMAN Inositol-trisphosphate 3-kinase A (Gene Name=ITPKA)

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