Structure of PDB 8ppd Chain B

Receptor sequence
>8ppdB (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMSWVQLATGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAF
HGVVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTDMYKKMLA
VDPEAPAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSR
EQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLF
VHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLI
GILASLAER
3D structure
PDB8ppd Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity
ChainB
Resolution1.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.127: inositol-trisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 75I B K264 M288 K312 Y315 R319 K419 K80 M94 K110 Y113 R117 K217
BS02 ATP B H185 T195 S197 F198 D250 L251 K336 L401 D416 H3 T11 S13 F14 D66 L67 K134 L199 D214
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0032958 inositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ppd, PDBe:8ppd, PDBj:8ppd
PDBsum8ppd
PubMed38374076
UniProtP23677|IP3KA_HUMAN Inositol-trisphosphate 3-kinase A (Gene Name=ITPKA)

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