Structure of PDB 8ppc Chain B

Receptor sequence
>8ppcB (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMSWVQLGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHG
VVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRK
DMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIK
KADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEV
SEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWE
EGNREDGYLLGLDNLIGILASLAER
3D structure
PDB8ppc Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity
ChainB
Resolution1.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.127: inositol-trisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2KM B K264 R285 M288 K291 K312 Y315 M316 R319 K419 K78 R99 M102 K105 K126 Y129 M130 R133 K233
BS02 ATP B F198 K209 D250 L251 I415 D416 F12 K23 D64 L65 I229 D230
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0032958 inositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ppc, PDBe:8ppc, PDBj:8ppc
PDBsum8ppc
PubMed38374076
UniProtP23677|IP3KA_HUMAN Inositol-trisphosphate 3-kinase A (Gene Name=ITPKA)

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