Structure of PDB 8ppb Chain B

Receptor sequence
>8ppbB (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMSWVQGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGV
VERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKD
MYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKK
ADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVS
EFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEE
GNREDGYLLGLDNLIGILASLAER
3D structure
PDB8ppb Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.127: inositol-trisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3I2 B R285 M288 K291 K312 Y315 R319 K419 R98 M101 K104 K125 Y128 R132 K232
BS02 ATP B F198 K209 D250 L251 K336 L401 I415 D416 F11 K22 D63 L64 K149 L214 I228 D229
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0032958 inositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ppb, PDBe:8ppb, PDBj:8ppb
PDBsum8ppb
PubMed38374076
UniProtP23677|IP3KA_HUMAN Inositol-trisphosphate 3-kinase A (Gene Name=ITPKA)

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