Structure of PDB 8pp8 Chain B

Receptor sequence
>8pp8B (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMSWSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVER
DGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYK
KMLAVDPEAPTEEEHAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCS
TDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRH
EVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDG
YLLGLDNLIGILASLAER
3D structure
PDB8pp8 Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity
ChainB
Resolution1.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.127: inositol-trisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3IA B R285 K291 K312 Y315 R319 K419 R95 K101 K119 Y122 R126 K226
BS02 ANP B H185 F198 K209 Q249 D250 L251 I415 D416 H3 F8 K19 Q59 D60 L61 I222 D223
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0032958 inositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8pp8, PDBe:8pp8, PDBj:8pp8
PDBsum8pp8
PubMed38374076
UniProtP23677|IP3KA_HUMAN Inositol-trisphosphate 3-kinase A (Gene Name=ITPKA)

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