Structure of PDB 8pom Chain B

Receptor sequence
>8pomB (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
AWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHPPLESVDVR
QIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWSGGFYGVSSQYESL
EHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNF
LHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERG
AQHHIYRLVR
3D structure
PDB8pom Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings.
ChainB
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZUP B F233 A235 A304 S345 V347 M379 C380 F406 I408 F17 A19 A82 S109 V111 M143 C144 F170 I172
External links
PDB RCSB:8pom, PDBe:8pom, PDBj:8pom
PDBsum8pom
PubMed37770003
UniProtQ15562|TEAD2_HUMAN Transcriptional enhancer factor TEF-4 (Gene Name=TEAD2)

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