Structure of PDB 8pm3 Chain B

Receptor sequence
>8pm3B (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRL
LMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDK
GQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMC
DFGISGYLVCKPYMAPERINPELYSVKSDIWSLGITMIELAILRFPYDSW
GTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ
HPFFTLHESKGTDVASFVKLILG
3D structure
PDB8pm3 Crystal structure of MAP2K6 with a covalent compound GCL94
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.12.2: mitogen-activated protein kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZLE B Y64 A80 L131 M132 K138 L186 C196 F198 Y18 A34 L85 M86 K92 L140 C150 F152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8pm3, PDBe:8pm3, PDBj:8pm3
PDBsum8pm3
PubMed
UniProtP52564|MP2K6_HUMAN Dual specificity mitogen-activated protein kinase kinase 6 (Gene Name=MAP2K6)

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